Characters that fight against the main villain and normally saves others from harm.
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- Saitama
- Samuel Vimes
- Sans
- Santa Claus (Myth)
- Sayori
- SCP-049
- SCP-239
- SCP-343
- Shovel Knight
- Shuuya Kano
- Sigurd (Fire Emblem)
- Snow Miser
- Solaire of Astora
- Solomon (NES Godzilla)
- Sonic the Hedgehog (Pre-Super Genesis Wave)
- Sonic the Hedgehog (Sonic X)
- Spider-Man (Marvel Comics)
- Spider-Man (The Amazing Spider-Man)
- Splash Woman (Mega Man)
- SpongeBob SquarePants
- Star Butterfly
- Starfire (Teen Titans)
- Suezo
- Superman (Earth-Two)
- Superman (Post-Crisis)
- Sword of Ditto
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